A FRAMEWORK FOR THE DESIGN, CONDUCT AND INTERPRETATION OF RANDOMISED CONTROLLED TRIALS IN THE PRESENCE OF TREATMENT CHANGES

A framework for the design, conduct and interpretation of randomised controlled trials in the presence of treatment changes

Abstract Background When a randomised trial is subject to deviations from randomised treatment, analysis according to intention-to-treat does not estimate two important quantities: relative treatment efficacy and effectiveness in a setting different from that in the trial.Even in trials of a predominantly pragmatic nature, there may be numerous rea

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Experimental and numerical investigation of Engineered Injection and Extraction (EIE) induced with three-dimensional flow field

In situ groundwater remediation technique is a commonly adopted method for the treatment of contaminated groundwater and the porous media associated Meal Delivery Carts with it.Engineered Injection and Extraction (EIE) has evolved as an improved methodology for in situ remediation, where sequential injection and extraction of clean water around the

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